# Detection of gastric cancer with implantation metastasis to the inguinal region via 18F-FAPI PET/CT: a case report

**Authors:** Haibo Zhang, Shanhu Hao, Tong Wu, Zhongbao Wu, Xuantong Liu, Ying Xu, Peng Zhang, Ying Yan

PMC · DOI: 10.3389/fonc.2025.1549825 · Frontiers in Oncology · 2025-07-08

## TL;DR

A rare case of gastric cancer spreading to the inguinal area was detected using FAPI PET/CT, leading to successful treatment.

## Contribution

Demonstrates the effectiveness of FAPI PET/CT in detecting implantation metastasis of gastric cancer missed by FDG PET/CT.

## Key findings

- Implantation metastasis was confirmed in the inguinal region via FAPI PET/CT.
- The patient showed a favorable prognosis after timely treatment based on the imaging findings.

## Abstract

Implantation metastasis of gastric cancer to the inguinal area is rarely reported, and a clear diagnosis of such metastasis is hard to make, especially when these cancers are invisible on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging. However, certain types of cancers, such as signet-ring cell carcinoma, are particularly sensitive to fibroblast activation protein inhibitor (FAPI) PET/CT. In this case, a patient with a history of gastric cancer and a gastrectomy 2 years previously suddenly developed serious edema in his right lower limb. With the help of FAPI PET/CT and other laboratory findings, abdominal implantation of his primary gastric cancer to the inguinal region was confirmed. After prompt treatment, the patient had a favorable prognosis.

## Linked entities

- **Chemicals:** fluorodeoxyglucose (PubChem CID 53716604)
- **Diseases:** gastric cancer (MONDO:0001056), signet-ring cell carcinoma (MONDO:0005092)

## Full-text entities

- **Diseases:** gastric cancer (MESH:D013274), edema (MESH:D004487), cancers (MESH:D009369), signet-ring cell carcinoma (MESH:D018279), metastasis (MESH:D009362)
- **Chemicals:** 18F-FAPI (-), FDG (MESH:D019788)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12279501/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12279501/full.md

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Source: https://tomesphere.com/paper/PMC12279501