# Uterine Spindle Cell Sarcoma Presenting With Lower Gastrointestinal Bleeding: A Case Report

**Authors:** Ahmad Habbas, Ismail Althunibat, Shatha Elemian, Byron Okwesili, Abdul Aishat Abiola, Laith Sorour, Amro Al Radaideh, Andre Fedida

PMC · DOI: 10.7759/cureus.86486 · Cureus · 2025-06-21

## TL;DR

A rare case of uterine spindle cell sarcoma presented as lower gastrointestinal bleeding in an elderly woman, highlighting unusual symptoms of this aggressive cancer.

## Contribution

This case report adds to the limited literature on uterine spindle cell sarcoma presenting with atypical gastrointestinal symptoms.

## Key findings

- A 79-year-old woman presented with lower GI bleeding, constipation, and weight loss due to uterine spindle cell sarcoma.
- Colonoscopy revealed an ulcerated mass in the sigmoid colon, confirmed as high-grade spindle cell sarcoma via biopsy.
- The mass was unresectable, leading to chemotherapy as the primary treatment.

## Abstract

This case report presents a rare clinical manifestation of uterine spindle cell sarcoma, an aggressive and uncommon malignancy, in a 79-year-old female patient. The patient presented with lower gastrointestinal (GI) bleeding, constipation, and significant weight loss. Colonoscopy identified an infiltrative, ulcerated mass within the sigmoid colon, later confirmed by biopsy as a high-grade spindle cell sarcoma of uterine origin. Given the unresectable status of the mass, chemotherapy was initiated as the primary treatment. This report discusses the diagnostic challenges and highlights the importance of considering atypical presentations in patients with lower GI bleeding and weight loss.

## Full-text entities

- **Diseases:** weight loss (MESH:D015431), uterine (MESH:D014591), GI bleeding (MESH:D006471), malignancy (MESH:D009369), Uterine Spindle Cell Sarcoma (MESH:D012509), constipation (MESH:D003248)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12279324/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12279324/full.md

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Source: https://tomesphere.com/paper/PMC12279324