# ZAP-X: An Innovative Radiosurgical Solution for Glomus Jugulare Tumors

**Authors:** Chengcheng Wang, Jinyuan Wang, Jingmin Bai, Longsheng Pan, Pengfei Xu, Baolin Qu, Xiangkun Dai

PMC · DOI: 10.7759/cureus.86495 · Cureus · 2025-06-21

## TL;DR

This study shows that the ZAP-X system can safely and effectively reduce tumor size in patients with glomus jugulare tumors.

## Contribution

The study presents novel clinical evidence of the ZAP-X system's effectiveness for treating glomus jugulare tumors.

## Key findings

- Tumor volumes significantly reduced after treatment with the ZAP-X system.
- No severe radiation therapy-related complications were observed in treated patients.
- The ZAP-X system shows potential for treating complex skull base tumors safely.

## Abstract

This study evaluated the clinical benefit of the application of the ZAP-X stereotactic radiosurgery (SRS) system in the treatment of glomus jugulare tumors. Two patients with recurrent or progressive glomus jugulare tumors underwent treatment with the ZAP-X SRS system. Analysis of clinical treatment processes and follow-up data over a period of up to three years revealed that after treatment with the ZAP-X system, the tumor volumes significantly reduced, and no severe radiation therapy-related complications were observed. These findings highlight the potential clinical benefits of the ZAP-X system in the treatment of complex skull base tumors.

## Full-text entities

- **Diseases:** skull base tumors (MESH:D019292), Glomus Jugulare Tumors (MESH:D010235), tumor (MESH:D009369)
- **Chemicals:** ZAP-X (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12279319/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12279319/full.md

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Source: https://tomesphere.com/paper/PMC12279319