# Implications From the Analogous Relationship Between Evolutionary and Learning Processes

**Authors:** Jason Cheok Kuan Leong, Masaaki Imaizumi, Hideki Innan, Naoki Irie

PMC · DOI: 10.1002/bies.70027 · Bioessays · 2025-06-08

## TL;DR

This paper explores how evolutionary processes and machine learning are similar, suggesting that understanding these parallels can improve predictions in both fields.

## Contribution

The paper introduces opportunities for using interpretable machine learning to discover common laws in evolutionary biology.

## Key findings

- Evolutionary biology and machine learning share conceptual parallels that can be mutually beneficial.
- White-box modeling can expand predictive theory in evolutionary science.
- Interpretable machine learning approaches may lead to new theoretical frameworks.

## Abstract

Organismal evolution is a process of discovering better‐fitting phenotypes through trial and error across generations. This iterative process resembles learning processes, an analogy recognized since the 1950s. Recognizing this parallel suggests that evolutionary biology and machine learning can mutually benefit from each other; however, ample opportunities for research into their corresponding concepts remain. In this review, we aim to enhance predictive capabilities and theoretical developments in both fields by exploring their conceptual parallels through specific examples that have emerged from recent advances. We focus on the importance of moving beyond predictions by machine learning approaches for specific cases, but instead advocate for interpretable machine learning approaches for discovering common laws for predicting evolutionary outcomes. This approach seeks to establish a theoretical framework that can transform evolutionary science into a field enriched with predictive theory while also inspiring new modeling and algorithmic strategies in machine learning.

Organismal evolution resembles learning processes in many aspects, but the analogy has not been widely recognized. We discuss new opportunities inspired by this analogy to enhance predictive capabilities and theoretical developments in both research fields, especially using white‐box modeling for expanding predictive theory in evolutionary biology.

## Full-text entities

- **Genes:** BMP2 (bone morphogenetic protein 2) [NCBI Gene 650] {aka BDA2, BMP2A, SSFSC, SSFSC1}, MDM4 (MDM4 regulator of p53) [NCBI Gene 4194] {aka BMFS6, HDMX, MDMX, MRP1}, SHH (sonic hedgehog signaling molecule) [NCBI Gene 6469] {aka HHG1, HLP3, HPE3, MCOPCB5, SMMCI, ShhNC}
- **Diseases:** Melanoma Skin Cancer (MESH:D012878), Tumor (MESH:D009369), prostate cancer (MESH:D011471), parasitic infections (MESH:D010272)
- **Species:** Felis catus (cat, species) [taxon 9685], Homo sapiens (human, species) [taxon 9606], Canis lupus familiaris (dog, subspecies) [taxon 9615], Orthomyxoviridae (family) [taxon 11308], Kallima inachus (dead leaf butterfly, species) [taxon 311037]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12278808/full.md

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12278808/full.md

## References

105 references — full list in the complete paper: https://tomesphere.com/paper/PMC12278808/full.md

---
Source: https://tomesphere.com/paper/PMC12278808