Aqueous−humor biomarkers and real−world efficacy of conbercept for diabetic macular edema: a prospective study in elderly patients

TL;DR

This study shows that conbercept treatment improves vision in elderly patients with diabetic macular edema, with biomarkers like VEGF and IL-6 potentially predicting better outcomes.

Contribution

The study evaluates conbercept's real-world efficacy and explores the predictive value of aqueous-humor biomarkers in elderly DME patients.

Findings

Conbercept improved visual acuity by about nine ETDRS letters and reduced retinal thickness in elderly DME patients.

Higher baseline VEGF and IL-6 levels were associated with greater anatomical improvement and better visual outcomes.

VEGF showed fair ability to predict treatment response, suggesting potential use in a multi-marker panel for DME.

Abstract

To evaluate real−world efficacy of conbercept and the predictive value of aqueous−humor biomarkers in elderly diabetic macular edema (DME).

In this single−arm, prospective study, 150 patients ≥ 65 years received three monthly conbercept injections followed by pro−re−nata dosing over 6 months. Baseline vascular endothelial growth factor (VEGF) and interleukin−6 (IL−6) levels were quantified from aqueous humor; best−corrected visual acuity (BCVA) and central subfield thickness (CST) were monitored. Mixed−effects modelling and receiver−operating−characteristic (ROC) analysis explored associations between biomarkers and outcomes.

Mean BCVA improved by approximately nine ETDRS letters, and CST declined by about 85 µm at Month 6. Higher baseline VEGF and IL−6 were associated with greater CST reduction and moderately increased odds of a ≥ 15−letter gain; VEGF showed fair discriminative ability (AUC=0.74). Treatment was well−tolerated, with no unexpected ocular or systemic adverse events.

Conbercept produced meaningful anatomical and functional benefits in an elderly DME cohort. Baseline aqueous VEGF and IL−6, while not definitive stand−alone tests, may help identify eyes likely to achieve pronounced anatomical improvement and warrant further investigation as components of a multi−marker predictive panel.