# Postpartum indicators of stress injury and inflammatory factors in high-risk pregnancies by oxytocin combined with cervical balloon dilators

## TL;DR

Combining oxytocin with cervical balloon dilators helps reduce stress and inflammation in high-risk pregnancies, improving delivery safety.

## Contribution

The study demonstrates that combining oxytocin with cervical balloon dilators reduces oxidative stress and inflammation in high-risk pregnancies.

## Key findings

- The observation group had higher blood pressure and lower heart rate compared to the control group.
- Oxytocin combined with cervical balloon dilators led to lower levels of stress and inflammatory markers post-treatment.
- No significant difference in postpartum complications was observed between the two groups.

## Abstract

•Oxytocin combined with cervical balloon dilators improves postpartum stress in high-risk pregnancies.•Oxytocin in combination with cervical balloon dilators improves postpartum inflammation in high-risk pregnancies.•Oxytocin in combination with cervical balloon dilators may improve hemodynamics in high-risk pregnancies.•Oxytocin combined with Cervical balloon dilators can shorten the duration of labor and improve the safety of delivery in high-risk pregnancies.

Oxytocin combined with cervical balloon dilators improves postpartum stress in high-risk pregnancies.

Oxytocin in combination with cervical balloon dilators improves postpartum inflammation in high-risk pregnancies.

Oxytocin in combination with cervical balloon dilators may improve hemodynamics in high-risk pregnancies.

Oxytocin combined with Cervical balloon dilators can shorten the duration of labor and improve the safety of delivery in high-risk pregnancies.

This work analyzes the effect of the combination of Oxytocin (OXT) combined with cervical balloon dilators on stress injury indicators and inflammatory factors in pregnant women with high-risk pregnancies.

Ninety-three pregnant women with high-risk pregnancies from June 2021 to November 2023 were collected and analyzed retrospectively, of which 43 cases were induced by OXT (control group), and 50 cases were induced by OXT combined with cervical balloon dilators (observation group). The differences in blood pressure and Heart Rate (HR) between the two groups were compared, and the pre-and post-treatment oxidative stress indicators Norepinephrine (NE), Adrenaline (AD), and Cortisol (Cor) and the inflammatory factors Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Prostaglandin E2 (PGE2). In addition, postpartum complications were counted in both groups.

The observation group had higher BP and lower HR than the control group (p < 0.05). After treatment, NE, AD, Cor, TNF-α, IL-1β, IL-6, and PGE2 increased in both groups, but the observation group was lower than the control group (p < 0.05). In addition, there was no difference in the incidence of postpartum complications between the observation group and the control group (p > 0.05).

OXT combined with cervical balloon dilators can effectively ameliorate oxidative stress injury and reduce inflammatory response in high-risk pregnancy women.