# Sneddon’s syndrome: A case report with diagnostic approach and imaging review

**Authors:** Soukaina Beyyato, Zineb Yammouri, Hajar Ouazzani, Ismail Chaouche, Amal Akammar, Nizar El Bouardi, Meriem Haloua, Moulay Youssef Alaoui Lamrani, Mustapha Maaroufi, Meryem Boubbou, Badreeddine Alami

PMC · DOI: 10.1016/j.radcr.2025.06.041 · 2025-07-09

## TL;DR

This paper presents a case of Sneddon’s syndrome in a 41-year-old woman, highlighting its rare connection between skin symptoms and brain strokes.

## Contribution

The case emphasizes the importance of MRI and clinical evaluation for diagnosing Sneddon’s syndrome in young stroke patients.

## Key findings

- MRI showed bilateral ischemic lesions and cortical atrophy in the patient.
- Autoimmune and thrombophilia tests were negative, supporting a diagnosis of Sneddon’s syndrome.
- The case underscores the need to consider Sneddon’s syndrome in young patients with livedo racemosa and strokes.

## Abstract

Sneddon’s syndrome is a rare thrombotic vasculopathy characterized by the association of livedo racemosa and ischemic cerebrovascular events, typically affecting young to middle-aged women. We report the case of a 41-year-old woman who presented with sudden right-sided hemiparesis, expressive aphasia, and a history of livedo racemosa. MRI revealed bilateral ischemic lesions and cortical atrophy, while autoimmune and thrombophilia workups were negative. This case emphasizes the importance of considering Sneddon’s syndrome in young patients with recurrent strokes and livedo racemosa, and highlights the diagnostic value of MRI combined with clinical evaluation.

## Linked entities

- **Diseases:** Sneddon’s syndrome (MONDO:0008436)

## Full-text entities

- **Diseases:** thrombophilia (MESH:D019851), livedo racemosa (MESH:D054068), autoimmune (MESH:D001327), ischemic lesions (MESH:D017202), Sneddon's syndrome (MESH:D018860), ischemic (MESH:D002545), hemiparesis (MESH:D010291), thrombotic vasculopathy (MESH:D013927), strokes (MESH:D020521), aphasia (MESH:D001037), cortical atrophy (MESH:D001284)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12274741/full.md

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Source: https://tomesphere.com/paper/PMC12274741