# Resolution of hypokalemia following nephrectomy for a presumed renal cell carcinoma revealing a large angiomyolipoma: A case report

**Authors:** Fatemeh Khajeh, Shahryar Zeighami, Ali Ariafar, Zahra Bazargani, Hossein Hakimelahi

PMC · DOI: 10.1016/j.eucr.2025.103108 · Urology Case Reports · 2025-07-01

## TL;DR

A patient with hypokalemia and suspected kidney cancer was found to have a benign tumor, resolving his symptoms after surgery.

## Contribution

Highlights the diagnostic challenge of minimal-fat angiomyolipomas mimicking renal cell carcinoma and the potential for kidney-sparing surgery.

## Key findings

- A 56-year-old male with hypokalemia and paralysis had a radical nephrectomy due to suspected RCC.
- Histopathology revealed an 8 cm angiomyolipoma instead of cancer, and hypokalemia resolved post-surgery.
- The case suggests accurate preoperative diagnosis could have allowed a less invasive surgical approach.

## Abstract

Renal angiomyolipomas (AMLs) are benign tumors that can mimic renal cell carcinoma (RCC) when fat content is minimal. We report a 56-year-old male with recurrent paralysis and hypokalemia, presumed to be a paraneoplastic syndrome of RCC, prompting radical nephrectomy. Histopathology and immunohistochemistry (IHC) revealed an 8 cm AML, and hypokalemia resolved post-surgery. This case underscores the diagnostic challenge of minimal-fat AMLs and suggests that an accurate preoperative diagnosis could have enabled kidney-sparing surgery.

## Linked entities

- **Diseases:** hypokalemia (MONDO:0003019), renal cell carcinoma (MONDO:0005086), paraneoplastic syndrome (MONDO:0021073)

## Full-text entities

- **Diseases:** benign tumors (MESH:D009369), paraneoplastic syndrome (MESH:D010257), RCC (MESH:D002292), hypokalemia (MESH:D007008), AMLs (MESH:D018207), paralysis (MESH:D010243), AML (MESH:D015470)

## Full text

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## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12273241/full.md

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Source: https://tomesphere.com/paper/PMC12273241