# Muhenrins A–C, pimarane-type diterpenoids from Munronia henryi

## TL;DR

Researchers discovered three new diterpenoids from a plant called Munronia henryi and studied their structures and potential anti-inflammatory effects.

## Contribution

The discovery of three new pimarane-type diterpenoids and their structural elucidation with biosynthetic insights.

## Key findings

- Muhenrin A has a unique 6,7-seco pimarane skeleton with proposed biosynthetic pathways.
- Compounds 1–4 showed weak inhibition of NO production in LPS-induced RAW 264.7 cells.
- Structures were confirmed using spectroscopic methods and X-ray diffraction.

## Abstract

Three undescribed pimarane-type diterpenoids, muhenrins A–C (1–3), along with a known analogue were isolated from the petroleum ether extract of Munronia henryi (Meliaceae). Their structures, including absolute configurations, were elucidated by means of various spectroscopic methods (IR, UV, HR-ESI-MS, NMR), single-crystal X-ray diffraction, ECD and NMR calculations. Muhenrin A (1) features a unique 6,7-seco pimarane skeleton, and its putative biosynthetic pathways have been proposed. Compounds 1–4 showed weak inhibitory activity against NO production in LPS-induced RAW 264.7 cells, with inhibition rates ranging from 13.73 – 32.35% at 50 μM concentrations.

Three pimarane-type diterpenoids, muhenrins A–C (1–3), along with a known analogue were isolated from Munronia henryi (Meliaceae).