# Synergistic roles of NFATc1 and c-Jun in immunomodulation

## TL;DR

This review explores how NFATc1 and c-Jun work together to regulate immune responses and their potential in treating immune-related diseases.

## Contribution

The paper provides a comprehensive overview of the synergistic roles of NFATc1 and c-Jun in immune regulation and their therapeutic implications.

## Key findings

- NFATc1 and c-Jun regulate immune cell activation and differentiation, especially in T-cells.
- They bind to overlapping DNA regions and modulate cytokine expression like IL-2 and TNF-α.
- Abnormal activity of these transcription factors is linked to autoimmune diseases, cancer, and inflammation.

## Abstract

The immune system relies on precise regulatory mechanisms, with transcription factors being central to modulating immune responses. NFATc1 and c-Jun are key transcription factors that influence both adaptive and innate immunity. This review provides a comprehensive examination of the individual and synergistic roles of NFATc1 and c-Jun in immune regulation. We delve into their molecular mechanisms, regulatory pathways, and the latest experimental approaches used to study these interactions. Furthermore, we explore the therapeutic potential of targeting these transcription factors, highlighting their clinical implications in treating immune-related diseases. This analysis underscores the critical importance of NFATc1 and c-Jun, paving the way for innovative and better therapeutic strategies and future research in immune regulation research.

•NFATc1 and c-Jun as key regulators: NFATc1 and c-Jun are pivotal transcription factors that regulate immune cell activation and differentiation, particularly in T-cells.•Mechanisms of cooperation: Both transcription factors bind to overlapping DNA regions, and their interaction is essential for modulating the expression of cytokines, such as IL-2 and TNF-α.•Immune modulation in T-cells and beyond: NFATc1 and c-Jun regulate immune responses not only in T-cells but also in other immune cells.•Pathological relevance: Aberrant NFATc1 and c-Jun activity is implicated in autoimmune diseases, cancer, and chronic inflammation.•Experimentalinsights and therapeutic prospects: In vitro and in vivo models have demonstrated the critical interactions between NFATc1 and c-Jun.

NFATc1 and c-Jun as key regulators: NFATc1 and c-Jun are pivotal transcription factors that regulate immune cell activation and differentiation, particularly in T-cells.

Mechanisms of cooperation: Both transcription factors bind to overlapping DNA regions, and their interaction is essential for modulating the expression of cytokines, such as IL-2 and TNF-α.

Immune modulation in T-cells and beyond: NFATc1 and c-Jun regulate immune responses not only in T-cells but also in other immune cells.

Pathological relevance: Aberrant NFATc1 and c-Jun activity is implicated in autoimmune diseases, cancer, and chronic inflammation.

Experimentalinsights and therapeutic prospects: In vitro and in vivo models have demonstrated the critical interactions between NFATc1 and c-Jun.