# The targeting of AKR1C1 synergizes with gefitinib via the STAT3 signaling pathway in EGFR-mutated NSCLC

**Authors:** Linlin Chang, Shuzhen Wei, Xiaotian Qi, Yang Gao, Jinhua Chen, Yu Cui, Pengxing He, Wenzhou Zhang

PMC · DOI: 10.1016/j.gendis.2025.101633 · Genes & Diseases · 2025-04-10

## Full-text entities

- **Genes:** AKR1C1 (aldo-keto reductase family 1 member C1) [NCBI Gene 1645] {aka 2-ALPHA-HSD, 20-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, STAT3 (signal transducer and activator of transcription 3) [NCBI Gene 6774] {aka ADMIO, ADMIO1, APRF, HIES}
- **Chemicals:** gefitinib (MESH:D000077156)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12272410/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12272410/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12272410/full.md

---
Source: https://tomesphere.com/paper/PMC12272410