# Uncharted territory: retinal vasculitis and cryoglobulinemia in Behçet’s disease – a case report

## TL;DR

A rare case of Behçet’s disease combined with HCV-related cryoglobulinemia and retinal vasculitis is reported, highlighting the need for complex treatment strategies.

## Contribution

This paper documents a rare coexistence of Behçet’s disease and mixed cryoglobulinemia, offering insights into its management.

## Key findings

- The patient exhibited retinal vasculitis, purpuric skin lesions, and systemic vasculitis linked to BD and cryoglobulinemia.
- Treatment required escalation from corticosteroids to immunosuppressants and antiviral agents for disease control.
- The case emphasizes the importance of a multidisciplinary approach in managing complex BD presentations.

## Abstract

Behçet’s disease (BD) is a systemic inflammatory disorder characterized by recurrent oral and genital ulcers, skin lesions, and ocular involvement, often presenting with retinal vasculitis as a severe complication. Although mixed cryoglobulinemia, typically associated with hepatitis C virus (HCV) infection, is well-documented in other autoimmune diseases, its coexistence with BD is exceedingly rare. This report details the case of a 56-year-old male presenting with BD complicated by HCV-related mixed cryoglobulinemia, manifesting as retinal vasculitis, purpuric skin lesions, and systemic vasculitis. Despite initial corticosteroid treatment, the patient required escalated therapy, including immunosuppressants and antiviral agents, to achieve disease stability. This case underscores the need for a multidisciplinary approach in managing BD with secondary cryoglobulinemia and highlights the complex interplay between autoimmune and viral-induced vasculitis. Our findings contribute to the literature by documenting a rare presentation of BD and providing insights into comprehensive treatment strategies for similar cases.