# An AIDS Patient With Pneumocystis jiroveci Pneumonia

**Authors:** Nicholas R Munoz, Armin Hojjat, Ajay Adial

PMC · DOI: 10.7759/cureus.86237 · Cureus · 2025-06-17

## TL;DR

This paper describes an AIDS patient who developed a fungal lung infection and was successfully treated with standard medication and supportive care.

## Contribution

The paper highlights the importance of recognizing and treating Pneumocystis pneumonia in immunocompromised patients.

## Key findings

- The patient's pneumonia was diagnosed as Pneumocystis jiroveci pneumonia (PCP).
- Treatment with TMP-SMX and supportive care led to clinical improvement.
- PCP should be considered in immunocompromised individuals with pneumonia.

## Abstract

Pneumocystis jiroveci is a fungus that is a common opportunistic infection in immunocompromised patients, especially acquired immunodeficiency syndrome (AIDS) patients. First-line treatment is trimethoprim-sulfamethoxazole (TMP-SMX). We present the case of a 68-year-old male patient found to have AIDS after being non-compliant with human immunodeficiency virus (HIV) medications for 15 years. He had bilateral pneumonia that was found to be Pneumocystis pneumonia (PCP) caused by Pneumocystis jiroveci. He was treated with TMP-SMX and supportive therapy such as supplemental oxygenation and vasopressors. As his oxygen requirements decreased, he was weaned off vasopressors, his mentation improved, and he was subsequently downgraded from the ICU. PCP should be suspected in immunocompromised individuals with pneumonia. In AIDS patients with PCP, TMP-SMX is the treatment of choice. TMP-SMX should be continued prophylactically until CD4 counts improve.

## Linked entities

- **Chemicals:** trimethoprim-sulfamethoxazole (PubChem CID 358641), TMP-SMX (PubChem CID 5578)
- **Diseases:** AIDS (MONDO:0012268), Pneumocystis pneumonia (MONDO:0019121), pneumonia (MONDO:0005249)

## Full-text entities

- **Genes:** CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** opportunistic infection (MESH:D009894), PCP (MESH:D011020), pneumonia (MESH:D011014), AIDS (MESH:D000163)
- **Chemicals:** TMP-SMX (MESH:D015662), oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12270505/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12270505/full.md

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Source: https://tomesphere.com/paper/PMC12270505