# CAFR-Net: A transformer-contrastive framework for robust spinal MRI segmentation via global-local synergy

**Authors:** Rui Ma, Xuegang Dai, Zuochao Yang, Zhixiong Wei, Bin Zhang

PMC · DOI: 10.1371/journal.pone.0327642 · PLOS One · 2025-07-17

## TL;DR

This paper introduces CAFR-Net, a new AI framework that improves the accuracy of spinal MRI segmentation by combining global and local features.

## Contribution

The novel contribution is a Transformer-contrastive framework that integrates global and local modeling for robust spinal MRI segmentation.

## Key findings

- CAFR-Net outperforms existing methods on the SpineMRI dataset with a Dice score of 92.04%.
- The framework achieves a Hausdorff Distance of 3.52 mm and an mIoU of 89.31%.
- The method demonstrates strong generalizability for clinical spinal image analysis.

## Abstract

Automated spinal structure segmentation in sagittal MRI remains a non-trivial task due to high inter-patient variability and ambiguous anatomical boundaries. We propose CAFR-Net, a Transformer-contrastive hybrid framework that jointly models global semantic relations and local anatomical priors to enable precise multi-class segmentation. The architecture integrates (1) a multi-scale Transformer encoder for long-range dependency modeling, (2) a Locally Adaptive Feature Recalibration (LAFR) module that reweights feature responses across spatial-channel dimensions, and (3) a Contrastive Learning-based Regularization (CLR) scheme enforcing pixel-level semantic alignment. Evaluated on the SpineMRI dataset, CAFR-Net achieves state-of-the-art performance, surpassing prior methods by a significant margin in Dice (92.04%), HD (3.52 mm), and mIoU (89.31%). These results underscore the framework’s potential as a generalizable and reproducible solution for clinical-grade spinal image analysis.

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12270114/full.md

## References

36 references — full list in the complete paper: https://tomesphere.com/paper/PMC12270114/full.md

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Source: https://tomesphere.com/paper/PMC12270114