# Autoimmune glial fibrillary acidic protein astrocytopathy suspected of intracranial infection: A case report

## TL;DR

This case report describes a rare autoimmune neurological disease and how it was diagnosed and treated despite initial suspicion of infection.

## Contribution

The paper highlights the use of negative mNGS results to rule out infection in a GFAP-A case and suggests preferred treatment approaches.

## Key findings

- GFAP-A can be misdiagnosed as intracranial infection.
- Negative mNGS results helped exclude infectious diseases in this case.
- Treatment plans for GFAP-A should focus on autoimmune management.

## Abstract

Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is an autoimmune-mediated neurological disease with cerebrospinal fluid GFAP-IgG as a marker. This is a rare disease. This paper reported a GFAP-A patient suspected intracranial infection whose diagnosis and treatment were summarized, and the value of negative metagenomic second-generation sequencing (mNGS) results for the exclusion of infectious diseases and the preferred treatment plan for GFAP-A were discussed.