# A Spindle Cell Tumor in Disguise: Histoid Nodules Arising From Peripheral Nerves

**Authors:** Akshdeep Singh Narula, Jerene Mathews, Pratik Minj, Ankur Patel

PMC · DOI: 10.7759/cureus.86173 · Cureus · 2025-06-16

## TL;DR

A young man with unusual skin nodules was diagnosed with a rare form of leprosy affecting peripheral nerves.

## Contribution

This case report highlights a rare presentation of histoid leprosy involving peripheral nerves.

## Key findings

- Spindle-shaped histiocytes and acid-fast bacilli were identified in the nodules.
- Ultrasonography confirmed a rare form of neural histoid leprosy.
- The nodules were linked to thickened superficial cutaneous nerves.

## Abstract

A 25-year-old male presented with multiple, painless subcutaneous nodules, each measuring 5-6 mm, attached to thickened superficial cutaneous nerves. He also had nodular infiltration of the left earlobe. Histopathology revealed spindle-shaped histiocytes in a storiform pattern, with numerous acid-fast bacilli in Fite-Faraco staining. Skin slit smear from the nodule revealed a bacteriological index of +6. Ultrasonography of the nodule revealed a well-defined, avascular, heterogenous hypoechoic lesion over a focally thickened nerve with loss of fibrillary pattern, confirming a rare form of neural histoid leprosy.

## Linked entities

- **Diseases:** leprosy (MONDO:0005124)

## Full-text entities

- **Diseases:** Spindle Cell Tumor (MESH:D002277), neural histoid leprosy (MESH:D015441)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12267876/full.md

## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12267876/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12267876/full.md

---
Source: https://tomesphere.com/paper/PMC12267876