# Morphological analysis of peritoneal fluid in fumarate hydratase deficiency-associated renal cell carcinoma: a case report

## TL;DR

This case report examines peritoneal fluid from a rare kidney cancer patient to improve diagnosis and understanding of FH-RCC.

## Contribution

The study presents unique cytological features of peritoneal fluid in FH-RCC, aiding in its differential diagnosis.

## Key findings

- Distinct cellular features were identified in the peritoneal fluid of an FH-RCC patient.
- The findings may enhance the recognition and management of FH-RCC through improved differential diagnosis.

## Abstract

Fumarate hydratase deficiency-associated renal cell carcinoma (FH-RCC) is a rare, aggressive subtype of renal cell carcinoma (RCC) driven by FH gene mutations. Its non-specific imaging features and heterogeneous pathological morphology complicate early diagnosis. This case report describes the cytological evaluation of peritoneal fluid from a 35-year-old male with FH-RCC, highlighting distinct cellular features within the effusion. These findings provide insights into the clinicopathological differential diagnosis of serous cavity effusions, potentially enhancing the recognition and management of this uncommon malignancy.