# Insights Into the Role of Streptococcus mutans and Candida albicans in Dental Biofilm Formation and Cariogenicity: A Literature Review

## TL;DR

This review explores how Streptococcus mutans and Candida albicans work together to cause tooth decay, highlighting their combined impact on acid production and biofilm formation.

## Contribution

The paper provides new insights into the synergistic virulence mechanisms of S. mutans and C. albicans in dental biofilms.

## Key findings

- Coaggregation of S. mutans and C. albicans increases acid production in biofilms.
- The interaction enhances cariogenic potential through polysaccharide production and virulence gene expression.
- The review highlights the need for targeted strategies to prevent dental caries based on these microbial interactions.

## Abstract

Dental caries is a widespread chronic disease that affects a large proportion of both adults and children globally. Streptococcus mutans is widely recognized as the primary pathogen responsible for dental caries, while Candida albicans frequently coexists with it, often forming a synergistic relationship. Despite this, the specific virulence mechanisms of these microorganisms, both individually and in coaggregation, as well as their collective impact on cariogenic potential, remain incompletely understood. This comprehensive review aims to examine both original and review articles addressing the virulence characteristics of these species, both independently and in coaggregation, and to assess how these interactions contribute to tooth demineralization, polysaccharide production, and the expression of virulence genes. The research reviewed here provides valuable insights into the physiological interactions between the two species, showing that these interactions lead to increased acid production within their coexisting biofilm, which enhances the cariogenic potential. These insights could guide future studies aimed at developing targeted strategies for preventing or mitigating dental caries.