# Featured Cover

**Authors:** Estevão Scudese, Andrea G. Marshall, Zer Vue, Vernat Exil, Benjamin I. Rodriguez, Mert Demirci, Larry Vang, Edgar Garza López, Kit Neikirk, Bryanna Shao, Han Le, Dominique Stephens, Duane D. Hall, Rahmati Rostami, Taylor Rodman, Kinuthia Kabugi, Jian‐qiang Shao, Margaret Mungai, Salma T. AshShareef, Innes Hicsasmaz, Sasha Manus, Celestine N. Wanjalla, Aaron Whiteside, Revathi Dasari, Clintoria R. Williams, Steven M. Damo, Jennifer A. Gaddy, Brian Glancy, Estélio Henrique Martin Dantas, André Kinder, Ashlesha Kadam, Dhanendra Tomar, Fabiana Scartoni, Matheus Baffi, Melanie R. McReynolds, Mark A. Phillips, Anthonya Cooper, Sandra A. Murray, Anita M. Quintana, Nelson Wandira, Okwute M. Ochayi, Magdalene Ameka, Annet Kirabo, Sepiso K. Masenga, Chanel Harris, Ashton Oliver, Pamela Martin, Amadou Gaye, Olga Korolkova, Vineeta Sharma, Bret C. Mobley, Prasanna Katti, Antentor Hinton

PMC · DOI: 10.1111/acel.70170 · Aging Cell · 2025-07-16

## TL;DR

This study explores how mitochondrial structure changes with age in human skeletal muscle, focusing on the role of MFN-2.

## Contribution

The paper provides new insights into age-related mitochondrial changes mediated by MFN-2 in skeletal muscle.

## Key findings

- Aging leads to significant changes in mitochondrial structure in human skeletal muscle.
- MFN-2 plays a key role in these structural changes associated with aging.

## Abstract

Cover legend: The cover image is based on the article 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes by Estevão Scudese et al.,
https://doi.org/10.1111/acel.70054

## Linked entities

- **Genes:** MFN2 (mitofusin 2) [NCBI Gene 9927]
- **Species:** Homo sapiens (taxon 9606)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12266775/full.md

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Source: https://tomesphere.com/paper/PMC12266775