# Influenza filaments: a graveyard of postdocs no longer?

**Authors:** Emily A Bruce

PMC · DOI: 10.1038/s44318-025-00480-7 · The EMBO Journal · 2025-06-09

## TL;DR

A recent study shows that filamentous influenza viruses can better enter host cells even when antibodies are present.

## Contribution

The study reveals a new functional role for filamentous influenza virions in overcoming antibody defenses.

## Key findings

- Filamentous influenza virions are more effective at entering host cells in the presence of neutralizing antibodies.
- This finding suggests a potential advantage of filamentous morphology during virus infection.

## Abstract

Influenza virions can take a variety of shapes, from the classic spherical or kidney bean morphology found in most lab-adapted strains to much longer filamentous forms that can reach over 20 nm in length. In this issue of The EMBO Journal, Peterl et al (2025) show that filamentous morphology improves the ability of a virion to enter host cells in the presence of neutralizing antibodies, thus shedding a new light on a role for filaments in influenza virus infection.

A recent study shows that filamentous morphology improves the ability of influenza viruses to enter host cells in the presence of neutralizing antibodies.

## Full-text entities

- **Genes:** IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma) [NCBI Gene 8517] {aka AMCBX1, EDAID1, FIP-3, FIP3, Fip3p, IKK-gamma}, NEU1 (neuraminidase 1) [NCBI Gene 4758] {aka NANH, NEU, SIAL1}, MAP1LC3A (microtubule associated protein 1 light chain 3 alpha) [NCBI Gene 84557] {aka ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3}, mucin [NCBI Gene 100508689], RAB11A (RAB11A, member RAS oncogene family) [NCBI Gene 8766] {aka YL8}
- **Diseases:** influenza virus infection (MESH:D007251), infection (MESH:D007239)
- **Chemicals:** jasplakinolide (MESH:C057531), sialic acid (MESH:D019158)
- **Species:** Homo sapiens (human, species) [taxon 9606], Gallus gallus (bantam, species) [taxon 9031], Orthomyxoviridae (family) [taxon 11308]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12264257/full.md

## References

1 references — full list in the complete paper: https://tomesphere.com/paper/PMC12264257/full.md

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Source: https://tomesphere.com/paper/PMC12264257