# Successful Management of Subarachnoid Hemorrhage Complicated by Takotsubo Cardiomyopathy Using Distal Transradial Access (dTRA) Coiling and Integrated Pharmacotherapy Under Intra-aortic Balloon Pumping (IABP) Support: A Stroke-Heart Syndrome Case

**Authors:** Yu Okuma, Kazumoto Suzuki, Kentaro Shimoda, Akane Tanda, Goro Kido, Yukihide Kagawa

PMC · DOI: 10.7759/cureus.86068 · Cureus · 2025-06-15

## TL;DR

A 55-year-old woman with subarachnoid hemorrhage and Takotsubo cardiomyopathy was successfully treated using a combination of IABP, dTRA coiling, and targeted medications.

## Contribution

This case demonstrates a novel integrative approach to managing neurocardiac comorbidities outside a formal ICU.

## Key findings

- Multidisciplinary care with IABP and dTRA coiling stabilized the patient's condition.
- Pharmacologic strategies including ARNIs and MRAs improved outcomes.
- Successful management was achieved in a high care unit without ICU transfer.

## Abstract

Takotsubo cardiomyopathy (TCM) complicating subarachnoid hemorrhage (SAH) presents unique management challenges due to the risk of cardiogenic shock and cerebral ischemia. We report the case of a 55-year-old woman with SAH and severe TCM treated successfully through multidisciplinary care involving intra-aortic balloon pumping (IABP), endovascular aneurysm coiling via distal transradial access (dTRA), and a structured pharmacologic strategy, following hemodynamic stabilization, that included angiotensin receptor-neprilysin inhibitors (ARNIs), beta-blockers (BBs), mineralocorticoid receptor antagonists (MRAs), clazosentan, and perampanel. This case illustrates the feasibility of managing complex neurocardiac comorbidity using integrative, anticipatory strategies in a high care unit (HCU) managed directly by neurosurgeons, outside a formal intensive care unit (ICU).

## Linked entities

- **Chemicals:** clazosentan (PubChem CID 6433095), perampanel (PubChem CID 9924495)
- **Diseases:** subarachnoid hemorrhage (MONDO:0005099), Takotsubo cardiomyopathy (MONDO:0019018), cardiogenic shock (MONDO:0800175), cerebral ischemia (MONDO:0002679)

## Full-text entities

- **Genes:** MME (membrane metalloendopeptidase) [NCBI Gene 4311] {aka CALLA, CD10, CMT2T, NEP, SCA43, SFE}
- **Diseases:** neurocardiac comorbidity (MESH:D004194), cerebral ischemia (MESH:D002545), cardiogenic shock (MESH:D012770), aneurysm (MESH:D000783), SAH (MESH:D013345), TCM (MESH:D054549), Stroke-Heart Syndrome (MESH:D020521)
- **Chemicals:** perampanel (MESH:C551441), clazosentan (MESH:C109641)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12263485/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12263485/full.md

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Source: https://tomesphere.com/paper/PMC12263485