# Desymmetrization of Bisallylic Amides: A Catalytic Enantioselective Diastereoselective Chlorocyclization Strategy

## TL;DR

A new catalytic method efficiently creates chiral compounds with three adjacent centers using chlorocyclization of bisallylic amides.

## Contribution

A catalytic strategy for enantioselective and diastereoselective chlorocyclization of bisallylic amides is introduced.

## Key findings

- Chlorinated oxazines with three contiguous chiral centers were synthesized in high yields.
- The method achieved up to 99% enantioselectivity and high diastereoselectivity.
- N-chlorophthalimide was used effectively as the chlorinating reagent.

## Abstract

(DHQD)2PHAL-catalyzed diastereo­selective
and enantio­selective
chloro­cyclization reactions of bisallylic amides were achieved
with N-chloro­phthal­imide (NCP) as the
chlorinating reagent. A series of chlorinated oxazines bearing three
contiguous chiral centers were obtained in high yields (up to 99%),
high diastereo­selectivity
and excellent enantio­selectivity (up to 99% ee).