Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications
Yuqun Wang, Kexin Zhang, Chengxia Kan, Wenqiang Zhang, Xiaodong Sun, Lixin Li
TL;DR
This paper reviews how diet influences brown and beige fat, which can help manage metabolic diseases by boosting energy balance.
Contribution
The paper systematically reviews molecular mechanisms and dietary strategies to enhance brown and beige adipocyte function.
Findings
Dietary nutrients can regulate brown and beige adipocyte function through specific signaling pathways.
Macronutrients, micronutrients, and stimulants impact BAT functionality and metabolic health.
Targeted dietary strategies show therapeutic potential for treating metabolic disorders.
Abstract
Brown adipose tissue (BAT) and beige adipose tissue (beige fat) function as thermogenic organs, significantly influencing human metabolism through various mechanisms. Recent findings suggest that dietary nutrient supplementation targeting BAT offers innovative strategies for enhancing energy homeostasis and addressing metabolic diseases. Identifying the molecular mechanisms through which nutrition regulates the function of brown and beige adipocytes is essential for translating preclinical findings into clinical applications. This review initially delineates the physiological characteristics of BAT and elucidates the regulatory mechanisms underlying its metabolic functions and associated signaling pathways. Subsequently, we examine the impact of macronutrients, micronutrients, and nutritional stimulants on BAT functionality. Finally, we explore the therapeutic potential of refined…
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Taxonomy
TopicsAdipose Tissue and Metabolism · Muscle metabolism and nutrition · Diet and metabolism studies