# Haplo-hematopoietic stem cell transplantation and immunoradiotherapy for severe aplastic anemia complicated with nasopharyngeal carcinoma: A case report

## TL;DR

This case report describes a rare patient with both severe aplastic anemia and nasopharyngeal cancer who was successfully treated with a combination of stem cell transplant and radiotherapy.

## Contribution

The paper presents a novel treatment approach for the rare co-occurrence of SAA and NPC using sequential haploidentical HSCT and immunoradiotherapy.

## Key findings

- Haploidentical HSCT led to rapid hematologic recovery in the patient.
- Nimotuzumab combined with radiotherapy effectively treated the nasopharyngeal carcinoma.
- The sequential therapy approach showed promise for managing both diseases simultaneously.

## Abstract

Severe aplastic anemia (SAA) and nasopharyngeal carcinoma (NPC) are two different diseases and are life-threatening if left untreated. The co-occurrence of SAA and NPC is rare and presents a complex therapeutic paradox. This study reports a unique case of a patient diagnosed with both SAA and NPC. The patient initially underwent haploidentical hematopoietic stem cell transplantation (HSCT) to achieve rapid hematologic recovery, followed by nimotuzumab + radiotherapy for carcinoma treatment. This case suggests that sequential haploidentical HSCT and radiotherapy may represent a promising therapeutic strategy for patients with coexisting SAA and NPC.