# Optimizing the diagnosis and treatment of depression in primary care: the emerging role of vortioxetine treatment

**Authors:** José Ángel Alcalá, Verónica Olmo Dorado, Guadalupe del Pilar Arilla Herrera, Silvia López Chamón, Vicente Gasull Molinera

PMC · DOI: 10.3389/fpsyt.2025.1568777 · Frontiers in Psychiatry · 2025-07-01

## TL;DR

This paper discusses how primary care doctors can better diagnose and treat depression, highlighting vortioxetine as a promising option.

## Contribution

The paper emphasizes vortioxetine as a new and effective treatment option for depression in primary care settings.

## Key findings

- Primary care physicians are crucial for early depression detection and treatment.
- Vortioxetine is a well-tolerated and effective treatment for various depression patient profiles.
- Best practices for managing depression in primary care are explored.

## Abstract

The management of patients with major depressive disorder (MDD) in primary care (PC) represents a significant challenge and a great opportunity for early and effective intervention. Primary care physicians, as first-line physicians, play a key role in the identification, diagnosis and initial treatment of depression, often being the first and sometimes the only point of contact for these patients with the healthcare system. In this context, the search for effective and well-tolerated therapeutic strategies is constant, and vortioxetine represents a good pharmacological option within the therapeutic armamentarium available to the PC physician. This article explores best practices in the management of MDD from the PC perspective, addressing the specific challenges faced by these professionals and examining the potential role of vortioxetine in the treatment of different patient profiles.

## Linked entities

- **Chemicals:** vortioxetine (PubChem CID 9966051)
- **Diseases:** major depressive disorder (MONDO:0002009), depression (MONDO:0002050)

## Full-text entities

- **Diseases:** MDD (MESH:D003865), depression (MESH:D003866)
- **Chemicals:** vortioxetine (MESH:D000078784)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12259655/full.md

## References

104 references — full list in the complete paper: https://tomesphere.com/paper/PMC12259655/full.md

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Source: https://tomesphere.com/paper/PMC12259655