# Liver transplantation for the treatment of neuroendocrine liver metastases

## TL;DR

Liver transplantation can offer long-term survival for some patients with advanced neuroendocrine liver metastases when other treatments are not possible.

## Contribution

This review highlights liver transplantation as a potentially curative option for selected patients with unresectable neuroendocrine liver metastases.

## Key findings

- Orthotopic liver transplantation improves long-term survival in patients meeting eligibility criteria.
- Patient selection is crucial for successful outcomes with liver transplantation.
- A multidisciplinary approach is necessary to optimize treatment for neuroendocrine liver metastases.

## Abstract

Neuroendocrine liver metastases (NELM) are commonly observed in patients with advanced neuroendocrine tumors (NETs) and are associated with poor prognosis, primarily due to liver failure and hormone-related complications. While hepatic resection remains the standard surgical approach, orthotopic liver transplantation (OLT) has emerged as a potentially curative treatment in selected patients with unresectable disease. This review summarizes current evidence on the role of OLT in managing NELM, with a focus on patient selection criteria and existing clinical guidelines. Appropriate selection is essential, as improved long-term survival has been consistently demonstrated in patients who meet established eligibility parameters. In conclusion, OLT offers meaningful survival benefits for carefully selected patients with NELM. A multidisciplinary approach and ongoing research into prognostic markers and adjunctive therapies are critical to optimizing outcomes in this challenging clinical setting.