# Mapping the knowledge network of extracellular vesicles and angiogenesis in tumor-immune communication: a scientometric analysis

## TL;DR

This study maps the research landscape of extracellular vesicles and angiogenesis in tumor-immune communication, identifying key players, trends, and future directions.

## Contribution

A comprehensive scientometric analysis of extracellular vesicle-angiogenesis research, revealing collaboration networks and emerging subfields.

## Key findings

- Extracellular vesicle-angiogenesis research has grown significantly over 25 years, with global collaboration across 111 countries.
- Key subfields include tumor biology, inflammation, and regenerative medicine, with a focus on exosomes and tumor microenvironment.
- Shanghai Jiao Tong University leads in publication output, and Immunology and cancer are the primary research areas.

## Abstract

This study aims to explore the cooperative networks among authors, nations, organizations, and publications specializing in extracellular vesicle-angiogenesis, to evaluate the foundational knowledge, and to pinpoint future research directions and new topics.

We extracted all relevant articles from the Web of Science Core Collection (WoSCC) and reviews related to extracellular vesicle-angiogenesis published between January 1999 and December 2023, which met our inclusion criteria. We conducted author and keyword composition analyses using VOSviewer 1.6.18. Furthermore, we utilized Citespace 5.8 to analyze journals, institutions, countries, and keyword timezone maps to elucidate the knowledge network within this field.

The number of academic papers on extracellular vesicle-angiogenesis has steadily increased over the past 25 years. Researchers have closely collaborated globally, with 6,741 papers published in 4,393 academic journals across 111 countries or regions. Shanghai Jiao Tong University has the highest publication volume. Immunology and cancer are the primary focus areas, with Frontiers in Immunology and PLoS One being significant journals in this field. Cluster analysis results indicate that the relationship between extracellular vesicle-angiogenesis and tumors, inflammation, and regenerative medicine are the three main subfields in this domain. Current research hotspots include mesenchymal stem cells, exosomes, angiogenesis, circulating microRNAs, angiogenesis, and tumor microenvironment.

This bibliometric study utilized visualization techniques to develop a knowledge map of extracellular vesicle-angiogenesis, revealing the significance of extracellular vesicles in tumor evasion by regulating intercellular communication between tumor cells and immune cells, and discussed the potential of exosomal biomarkers in precision medicine.

Overview of the technical roadmap.

Bibliometric analysis flowchart showing two parts. Part I involves 6,741 articles and reviews. Part II focuses on the top 100 most cited articles. The topic includes terms related to extracellular vesicles and angiogenesis, sourced from the Web of Science core collection, limited to English, articles, and reviews from January 1999 to December 2023.