# Small Cell Type Poorly Differentiated Neuroendocrine Cancer of the Gallbladder

## TL;DR

A rare case of gallbladder neuroendocrine cancer is presented, highlighting the challenges in diagnosis and treatment due to its aggressive nature and late detection.

## Contribution

This paper reports a rare clinical case of poorly differentiated gallbladder neuroendocrine cancer with peritoneal metastasis.

## Key findings

- The patient presented with jaundice and was diagnosed with poorly differentiated neuroendocrine carcinoma of the gallbladder.
- The tumor had invaded adjacent organs and spread to the peritoneum, making surgical resection infeasible.
- Palliative chemotherapy was used as the primary treatment due to the advanced stage of the disease.

## Abstract

Neuroendocrine tumor (NET) is a rare gallbladder (GB) malignancy and is seldom seen in clinical practice. There is a scarcity of reported cases, or extensive studies, hence not much is known about the disease. We present here the case of a 62-year-old woman, presenting with jaundice as the only symptom. On subsequent investigations, it was diagnosed to be poorly differentiated neuroendocrine carcinoma (NEC) of the GB with invasion of adjoining organs and peritoneal metastasis and was managed with palliative chemotherapy. At present, the treatment of choice for GB NET is surgical resection, but it is possible in only very limited cases due to metastatic disease at the time of first presentation. Hence, in such cases, chemotherapy remains a feasible alternative.