P43 Determining the antibiotic resistance phenotypes of Klebsiella pneumoniae infections in children aged from 0 to 59 months in the health district of Koutiala in Mali from August 2023 to March 2024

TL;DR

This study analyzed antibiotic resistance in Klebsiella pneumoniae infections among children in Mali, finding high resistance to common antibiotics and identifying specific resistant strains.

Contribution

The study provides new insights into the antibiotic resistance profiles of K. pneumoniae in young children in a specific Malian health district.

Findings

25 K. pneumoniae strains were isolated, with 20 showing broad-spectrum resistance.

15 of the resistant strains were BLSE producers, and 5 were suspected carbapenemase producers.

Amikacin, cefotaxime, ertapenem, and meropenem showed the highest sensitivity.

Abstract

In the Koutiala region of Mali, preventing and effectively treating klebsiella pneumoniae infections children aged 0 to 59 months requires ongoing clinical research. Klebsiella pneumoniae is an enterobacteria responsible for many serious infections such as pneumoniae, especially nosocomial. Antibiotic resistance is a major problem and presents a challenge for the treatment of K. pneumoniae infections.

To study the antibiotic resistance phenotypes of K. pneumoniae 2024.

Human blood and urine samples were received and grown in the laboratory to isolate strains and determine resistance phenotypes

On the 2771 samples treated during our study, there were 623 positive or 22%. The most frequently found germs in the blood and urine were Escherichia coli, Salmonella spp., K. pneumoniae and Streptococcus pneumoniae. The distribution of K. pneumoniae strains 4% (25 strains) for positive samples. That is 64% in the blood and 36% in the urine. The number of isolated strains of K. pneumoniae was in favour of the male sex with 56% and 44% for the female sex. The number of isolate strains of K. pneumoniae was 64% for infants, 32% for children, and 4% for newborns. The services that recorded the most strains were the nutrition services and hospital paediatrics. For the future of patients 12% died during our study. Regarding antibiotic resistance, there was ampicillin, the combination trimethoprim+ sulfamethoxazole, ceftriaxone, amoxicillin + clavulanic acid, cefoxitin; aztreonam and cefepime. The most sensitive antibiotics were amikacin, cefotaxime, ertapenem and meropenem.

This study showed that 25 strains of K. pneumoniae were isolated, including 20 strains of BMR among which there were 15 strains of BLSE and 5 strains of suspected carbapenemases.