# Exploring the Efficacy of Benralizumab in Chronic Eosinophilic Pneumonia Following Corticosteroid Therapeutic Failure: A Case Report

**Authors:** Sofia De La O Villalobos, Pablo Olivas Melendez, Adriana Saenz Ramirez, Mariana Gonzalez Plascencia, Isai R Castillo Cabrera

PMC · DOI: 10.7759/cureus.87634 · 2025-07-09

## TL;DR

This case report explores the use of benralizumab in a patient with chronic eosinophilic pneumonia who did not respond to corticosteroids.

## Contribution

The novelty lies in reporting benralizumab's potential efficacy in treating corticosteroid-resistant chronic eosinophilic pneumonia.

## Key findings

- The patient's condition did not improve with corticosteroid therapy.
- Benralizumab was considered as an alternative treatment option.

## Abstract

Chronic eosinophilic pneumonia is a rare idiopathic disease characterized by eosinophilic infiltrates in the alveoli and interstitial lung spaces. There are no specific diagnostic tests for this condition, but it is suspected in patients presenting with dyspnea, cough, a tomographic pattern of consolidations, peripheral ground-glass opacities, and peripheral eosinophilia. This report presents the case of a male patient with chronic eosinophilic pneumonia that was unresponsive to corticosteroid treatment.

## Linked entities

- **Diseases:** chronic eosinophilic pneumonia (MONDO:0004806)

## Full-text entities

- **Diseases:** eosinophilia (MESH:D004802), cough (MESH:D003371), Chronic Eosinophilic Pneumonia (MESH:C535590), dyspnea (MESH:D004417)
- **Chemicals:** Benralizumab (MESH:C571386)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12257868/full.md

---
Source: https://tomesphere.com/paper/PMC12257868