Biochemical and Histological Characterization of Sorcin Overexpression in Patients Who Underwent Radical Prostatectomy

TL;DR

This study found that sorcin levels are higher in prostate cancer patients compared to healthy individuals and may be linked to cancer severity.

Contribution

The study is the first to compare serum sorcin levels with histopathological findings in prostate cancer patients after radical prostatectomy.

Findings

Prostate cancer patients had significantly higher sorcin levels than healthy controls.

Higher sorcin levels were associated with positive lymph nodes and biochemical recurrence.

Sorcin levels correlated with higher cancer grade groups but not with staining percentages.

Abstract

Sorcin, a signaling molecule, has recently emerged as a significant focus within cancer research. This study aimed to compare histopathology results with serum sorcin level and tissue sorcin immunohistochemical expression in patients who underwent radical prostatectomy (RP).

A total of 81 patients who underwent RP between December 2017 and June 2019 due to prostate cancer (PCa) and had not received any previous treatment were included in the study. Patients attended regular follow-up appointments for at least 24 months. In order to compare serum sorcin levels, the control group consisted of 67 healthy men. Demographic data of participants were recorded. In the PCa group, pathology data from both Transrectal ultrasound-guided biopsy and RP were documented.

Prostate-specific antigen (PSA) and sorcin levels of PCa patients were found to be higher than the control group (P < .001, P = .02). In the comparison of sorcin levels and sorcin staining percentages of PCa patients with histopathological and clinical findings; while sorcin levels were found to be higher in patients with positive lymph nodes (P = .018) and with biochemical recurrence (P = .049), no significant difference was found in any histopathological finding in terms of sorcin staining percentages. In an receiver operating characteristic curve analysis calculation for sorcin levels in PCa patients, AUC = 0.563 and when the cut-off value was taken as 0.415 ng/mL, 59.3% sensitivity 60.1% specificity was determined.

Sorcin was found to be higher in PCa compared to healthy males. In addition, high International Society of Urological Pathology grade groups were observed in patients with high sorcin levels.

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