# First-line Eradication of Helicobacter pylori Infection with High-Dose Amoxicillin and Vonoprazan: A Systematic Review and Meta-analysis

## TL;DR

This study compares high-dose amoxicillin and vonoprazan treatment for H. pylori infection and finds it as effective as previous treatments but with fewer side effects.

## Contribution

The study introduces a meta-analysis of high-dose amoxicillin and vonoprazan dual therapy for H. pylori eradication.

## Key findings

- High-dose amoxicillin and vonoprazan had similar eradication rates to previous regimens.
- The treatment caused significantly fewer adverse events compared to control regimens.
- In China, the high-dose regimen showed a higher eradication rate in ITT analysis.

## Abstract

Due to increasing Helicobacter pylori resistance, the effectiveness of proton pump inhibitor-based regimens has diminished. There is a need to assess the high-dose amoxicillin (≥3 g/day) and vonoprazan dual therapy through meta-analysis to determine if it is more effective than previous protocols.

A computer search of PubMed, Web of Science, Cochrane Library, Embase, and ClinicalTrials.gov was carried out to identify randomized controlled trials of massive dose amoxicillin and vonoprazan double treatment for H. pylori infection, up to June 2023. The primary outcome measures were the eradication rate and adverse event rate.

A total of 7 studies encompassing 2601 patients were analyzed. The eradication rate of the high-dose dual group has no statistically significant differences compared to the control group (non-high-dose amoxicillin combined with vonoprazan) in intention-to-treat (ITT) [OR=1.12, 95% CI (0.85, 1.48), P = .42] and per-protocol (PP) analysis [OR=1.08, 95% CI (0.74, 1.58), P = .69]. The incidence of adverse events [OR=0.63, 95% CI (0.45, 0.88), P = .007] was significantly reduced in the dual treatment group. Subgroup analysis revealed that the eradication rate in China [OR=1.34, 95% CI (1.01, 1.87), P = .04] was higher for the high-dose dual group compared with the control group in ITT analysis.

The eradication rate of high-dose amoxicillin and vonoprazan dual regimen is similar to that of previous regimens, and the adverse event rate is significantly lower.