# Lower eyelid angioleiomyoma: a rare case of a slowly progressive orbital tumor with a 10-year history

**Authors:** Amine Oussalem, Anas Azgaoui, Bouchra Dani, Malik Boulaadas

PMC · DOI: 10.1093/jscr/rjaf507 · 2025-07-14

## TL;DR

A rare case of a slowly growing eyelid tumor in a 60-year-old man is reported, diagnosed as angioleiomyoma after surgical excision and histopathological analysis.

## Contribution

This paper presents a new clinical case of angioleiomyoma in the orbital region, emphasizing its diagnostic challenges and management.

## Key findings

- The tumor was a 15 × 10 mm mass composed of smooth muscle bundles surrounding vascular channels.
- Immunohistochemistry confirmed the diagnosis with positivity for smooth muscle actin and desmin.
- No tumor recurrence was observed during a 3-year follow-up period.

## Abstract

Angioleiomyoma is a rare benign vascular smooth muscle tumor, exceptionally reported in the orbit and peri-orbital region with fewer than 25 cases documented. We report a case of a 60-year-old male presenting a slowly progressive, painless lower eyelid mass evolving over 10 years. Clinical examination revealed a well-circumscribed 15 mm lesion. Angio-computed tomography (CT) demonstrated a 22 × 24 × 18 mm well-circumscribed mass with peripheral contrast enhancement, consistent with a vascularized lesion. Surgical excision via a subciliary approach was performed. Histopathological analysis showed a 15 × 10 mm tumor composed of smooth muscle bundles surrounding vascular channels. Immunohistochemistry was positive for smooth muscle actin and desmin, confirming the diagnosis of angioleiomyoma. No recurrence was observed during a 3-year follow-up. The absence of magnetic resonance imaging (MRI), due to patient financial constraints, constitutes a limitation discussed herein. This case highlights the diagnostic challenge and the importance of considering angioleiomyoma in differential diagnoses of eyelid masses.

## Linked entities

- **Diseases:** angioleiomyoma (MONDO:0006646)

## Full-text entities

- **Genes:** DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}
- **Diseases:** eyelid masses (MESH:D005141), smooth muscle tumor (MESH:D018235), mass (MESH:C536030), orbital tumor (MESH:D009918), Angioleiomyoma (MESH:D018229), tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12257626/full.md

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Source: https://tomesphere.com/paper/PMC12257626