A Case Report of Coexistence of EGFR and ROS-1 Gene Mutations in Non-small Cell Lung Cancer

TL;DR

This paper reports a rare case of non-small cell lung cancer with both EGFR and ROS-1 gene mutations, offering insights for treatment strategies.

Contribution

The novelty lies in reporting a rare coexistence of EGFR and ROS-1 mutations in a single NSCLC case.

Findings

EGFR and ROS-1 gene mutations were found to coexist in a non-small cell lung cancer patient.

This case highlights the need for tailored treatment strategies for such rare genetic combinations.

Abstract

肺癌是当前世界上最常见的恶性肿瘤之一，其治疗已进入靶向治疗时代。表皮生长因子受体（epidermal growth factor receptor, EGFR）突变是非小细胞肺癌（non-small cell lung cancer, NSCLC）的常见基因突变类型，而c-ros原癌基因1受体酪氨酸激酶（c-ros oncogene 1 receptor tyrosine kinase, ROS-1）融合突变是NSCLC的罕见突变位点，目前关于合并EGFR和ROS-1基因突变共存的病例报道少见。本研究报道了1例合并EGFR和ROS-1基因突变共存的NSCLC病例，旨在为临床工作提供相关的治疗策略。

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