# A Case of Colchicine Overdose and Toxicity

**Authors:** Sneh Parekh, Ty J Merry, Vanshika Tripathi, Pramod Reddy

PMC · DOI: 10.7759/cureus.85948 · Cureus · 2025-06-13

## TL;DR

This paper presents a case of a young woman who suffered severe health issues due to a colchicine overdose and highlights the importance of early detection.

## Contribution

The paper contributes a detailed case study of colchicine overdose with clinical insights into its management.

## Key findings

- Colchicine overdose can cause severe abdominal pain and multiorgan failure.
- Early identification is crucial as there is no specific antidote for colchicine toxicity.
- The case highlights the clinical course and management of a 31-year-old female affected by colchicine overdose.

## Abstract

Colchicine is a commonly used medication that treats gout, familial Mediterranean fever, and pericarditis. Colchicine overdose is rarely seen; however, toxicity from colchicine overdose can have life-threatening consequences, precipitating multiorgan failure and death. Colchicine toxicity has a unique presentation that can result in severe abdominal pain, rhabdomyolysis, and leukopenia. Early identification of colchicine toxicity is necessary to help guide management, as no specific antidote exists. We present the case of a 31-year-old female who presented with severe abdominal pain and the sequelae of colchicine overdose, along with a discussion regarding her clinical course and management.

## Linked entities

- **Chemicals:** colchicine (PubChem CID 2833)
- **Diseases:** gout (MONDO:0005393), familial Mediterranean fever (MONDO:0009572), pericarditis (MONDO:0005904), rhabdomyolysis (MONDO:0005290), leukopenia (MONDO:0003785)

## Full-text entities

- **Diseases:** abdominal pain (MESH:D015746), pericarditis (MESH:D010493), Overdose (MESH:D062787), familial Mediterranean fever (MESH:D010505), leukopenia (MESH:D007970), multiorgan failure (MESH:D051437), death (MESH:D003643), gout (MESH:D006073), Toxicity (MESH:D064420), rhabdomyolysis (MESH:D012206)
- **Chemicals:** Colchicine (MESH:D003078)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12256117/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12256117/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12256117/full.md

---
Source: https://tomesphere.com/paper/PMC12256117