# Hyponatremia Presents With Seizure in a Patient With Arnold-Chiari Malformation: A Case Report

**Authors:** Mohamed Zuhail K Peediyakkal, Nabil Mahmood, Ashib Thurakkal, Nevin Kannappilly, Sunil Hassan Koya, Saifil Sidhique, Bara M Al-Qudah, Humam E Rajha, Abdulqadir J Nashwan

PMC · DOI: 10.7759/cureus.85819 · Cureus · 2025-06-11

## TL;DR

A rare case of hyponatremia causing seizures in a patient with Arnold-Chiari malformation is reported, highlighting a possible but underrecognized connection.

## Contribution

This case report introduces hyponatremic seizures as a rare and underrecognized manifestation of Arnold-Chiari malformation.

## Key findings

- Hyponatremia can present as seizures in patients with Arnold-Chiari malformation.
- The case highlights the need for increased clinical awareness of this rare association.
- The paper explores potential pathophysiological mechanisms linking ACM to hyponatremia.

## Abstract

Arnold-Chiari malformation (ACM) is a neuroanatomical disorder characterized by the displacement of cerebellar tonsils through the foramen magnum. While traditionally associated with a spectrum of neurological symptoms, hyponatremic seizures remain a rare and underrecognized presentation of ACM. This manuscript explores the potential pathophysiological mechanisms linking ACM to hyponatremia and presents a clinical case illustrating this unusual association. Although seizures are a well-documented manifestation of various neurological conditions, their occurrence secondary to hyponatremia in ACM patients has not been extensively reported in the literature. By examining this rare complication, we aim to enhance clinical awareness and deepen the understanding of the underlying mechanisms that may contribute to this phenomenon.

## Linked entities

- **Diseases:** Arnold-Chiari malformation (MONDO:0000115)

## Full-text entities

- **Diseases:** neuroanatomical disorder (MESH:D009358), ACM (MESH:D001139), Hyponatremia (MESH:D007010), Seizure (MESH:D012640)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12256028/full.md

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Source: https://tomesphere.com/paper/PMC12256028