# Treatment of an Osteochondral Defect of the Trochlea Using Matrix-Induced Autologous Chondrocyte Implantation and Proximal Tibia Autologous Bone Grafting

**Authors:** Rishi Trikha, Thomas J. Kremen, Paul J. Walker, Kristofer J. Jones

PMC · DOI: 10.1016/j.eats.2025.103507 · Arthroscopy Techniques · 2025-03-15

## TL;DR

This paper describes a modified technique combining MACI and bone grafting to treat a specific type of knee cartilage defect.

## Contribution

The paper introduces a modified MACI sandwich technique using a single scaffold and autologous bone graft.

## Key findings

- The modified MACI technique allows for a stable single-layer scaffold.
- The technique provides an efficient operative workflow for treating osteochondral defects.

## Abstract

Chondral and osteochondral defects of the knee are painful and disabling in the short term, can lead to accelerated osteoarthritis in the long term, and have relatively poor healing potential. Although many cartilage restoration procedures exist for focal cartilage defects, matrix-induced autologous chondrocyte implantation (MACI) for the appropriate patient has evolved as a reliable technique with encouraging long-term outcomes. Despite the reported favorable outcomes, there remains a relative dearth of literature on the use of MACI with autologous bone graft. This article presents a modified MACI sandwich technique that uses only 1 scaffold in combination with autologous bone graft from the proximal tibia to address an osteochondritis dissecans lesion of the lateral trochlea. This technique allows for both a stable MACI single-layer scaffold and a relatively efficient operative workflow.

## Linked entities

- **Diseases:** osteoarthritis (MONDO:0005178), osteochondritis dissecans (MONDO:0017178)

## Full-text entities

- **Diseases:** painful (MESH:D010146), cartilage defects (MESH:D002357), osteoarthritis (MESH:D010003), knee (MESH:D007718), Chondral and osteochondral defects (MESH:D010007), osteochondritis dissecans lesion (MESH:D010008)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12255428/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12255428/full.md

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Source: https://tomesphere.com/paper/PMC12255428