# Severe Drug-Induced Dermatosis in a Geriatric Patient: A Case Report

**Authors:** Stephanie Saldaña Guerrero, Sofia C Lanzarin Quezada, Quitzia L Torres Salazar

PMC · DOI: 10.7759/cureus.87781 · Cureus · 2025-07-12

## TL;DR

An elderly woman developed severe skin symptoms from drug reactions, highlighting the need for careful medication review in older adults.

## Contribution

This case report emphasizes the diagnostic challenges of drug-induced dermatoses in geriatric patients using multiple medications and natural products.

## Key findings

- A 71-year-old woman developed severe skin symptoms from drug reactions and self-medication.
- Hospitalization and corticosteroid treatment were required after outpatient care failed.
- The case underscores the importance of thorough medication review in elderly patients.

## Abstract

Older adults are particularly vulnerable to adverse drug reactions (ADRs) due to age-related physiological changes and polypharmacy. Among these, drug-induced dermatoses are common but often underdiagnosed, especially when presentation is atypical or when patients use unregulated treatments. We report the case of a 71-year-old woman who developed erythroderma, pruritus, and desquamation following the use of prescribed medications alongside topical and herbal self-medication. Hospitalization was required after outpatient treatment failed. Skin biopsy revealed an acute inflammatory pattern consistent with pharmacodermia. Conservative treatment with systemic corticosteroids and topical emollients achieved full remission without complications. This case highlights the diagnostic complexity of ADRs in older adults, particularly in the context of incomplete medication histories and the use of natural products. It emphasizes the need for heightened clinical suspicion, thorough medication review, and pharmacovigilance to prevent escalation of cutaneous toxicity in the elderly.

## Linked entities

- **Diseases:** erythroderma (MONDO:0043233)

## Full-text entities

- **Diseases:** erythroderma (MESH:D003873), drug reactions (MESH:D004342), Dermatosis (MESH:D012871), inflammatory (MESH:D007249), pruritus (MESH:D011537), cutaneous toxicity (MESH:D013262), desquamation (MESH:D017490)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12255369/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12255369/full.md

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Source: https://tomesphere.com/paper/PMC12255369