# Reversal of Type 2 Diabetes in a Patient With Hashimoto’s Thyroiditis Through Combined Pharmacologic and Lifestyle Intervention

## TL;DR

A 32-year-old woman with Type 2 diabetes and Hashimoto’s thyroiditis achieved diabetes remission after a year of medication and lifestyle changes.

## Contribution

This case demonstrates that Type 2 diabetes can be reversed through combined pharmacologic and lifestyle interventions in select patients.

## Key findings

- After 12 months of treatment, the patient's fasting glucose and HbA1c levels dropped below diabetes diagnostic thresholds.
- Metformin could be discontinued, and remission was sustained for six months post-intervention.
- The combination of metformin, levothyroxine, calorie deficit, and resistance training led to successful diabetes reversal.

## Abstract

Type 2 diabetes mellitus (T2DM) is typically considered a progressive condition, but recent evidence suggests potential reversibility through structured lifestyle intervention. We report the case of a 32-year-old Egyptian female with Hashimoto’s thyroiditis and newly diagnosed T2DM, confirmed by elevated fasting blood glucose and HbA1c levels. The patient was managed with once-daily metformin, continued levothyroxine, a 500-calorie daily energy deficit, and progressive resistance training three times per week. After 12 months, fasting glucose and HbA1c values decreased below the diagnostic thresholds for diabetes, allowing metformin to be discontinued. Follow-up at one, three, and six months post-intervention confirmed sustained biochemical remission. This case highlights the potential for reversing diabetes in select patients through a combined pharmacological and lifestyle approach.