# Zap-X Radiosurgery for Skull Base Meningiomas: A Long-Term Follow-Up Case Report

**Authors:** Jingmin Bai, Jinyuan Wang, Chengcheng Wang, Xiangkun Dai, Wei Yu, Longsheng Pan, Baolin Qu

PMC · DOI: 10.7759/cureus.86427 · Cureus · 2025-06-20

## TL;DR

This case report examines the long-term outcomes of two meningioma patients treated with ZAP-X radiosurgery, showing no major side effects or neurological issues over four years.

## Contribution

The study provides early evidence supporting the safety and potential clinical utility of ZAP-X radiosurgery for skull base meningiomas.

## Key findings

- No new neurological deficits were observed in either patient during up to four years of follow-up.
- No adverse events of grade 2 or higher occurred in the patients treated with ZAP-X.
- The results suggest ZAP-X may be a safe option for skull base meningioma treatment.

## Abstract

This article reports two cases of meningioma patients treated with the novel radiosurgical device ZAP-X stereotactic radiosurgery. During the long-term follow-up period of up to four years after treatment, neither patient developed new neurological deficits, and no adverse reactions of Common Terminology Criteria for Adverse Events grade 2 or above occurred. By retrospectively analyzing the clinical diagnosis, treatment processes, and follow-up results of these two patients, this study aims to provide practical references for the large-scale clinical application of this technology.

## Linked entities

- **Diseases:** meningioma (MONDO:0003057)

## Full-text entities

- **Diseases:** Meningiomas (MESH:D008579), neurological deficits (MESH:D009461)
- **Chemicals:** ZAP-X (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12254024/full.md

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Source: https://tomesphere.com/paper/PMC12254024