# An Unusual Cause of Abdominal Pain: Mesenteric Lymphadenopathy Secondary to Sarcoidosis Without Pulmonary Involvement

**Authors:** Brandon Wiggins, Chris Cenzer, John M Sullivan, Kyle Knight, Fady Banno, Nathan Landesman

PMC · DOI: 10.7759/cureus.85797 · Cureus · 2025-06-11

## TL;DR

This paper presents a rare case of sarcoidosis affecting the gastrointestinal tract and mesenteric lymph nodes without lung involvement, successfully treated with methotrexate.

## Contribution

The novelty lies in the rare presentation of sarcoidosis with GI and lymph node involvement but no pulmonary symptoms.

## Key findings

- GI sarcoidosis can present with mesenteric lymphadenopathy and no pulmonary involvement.
- Methotrexate was effective in treating this rare case of sarcoidosis.
- Biopsy is essential for diagnosing sarcoidosis in the GI tract.

## Abstract

Sarcoidosis is a systemic disease that affects multiple organs in the body but rarely affects the gastrointestinal (GI) tract. The symptoms of GI sarcoidosis may be nonspecific or silent. Often, it is discovered on computed tomography (CT) or esophagogastroduodenoscopy (EGD), and a biopsy is needed for diagnosis. Initial management is typically with prednisone; however, here, we present a rare case of GI sarcoidosis with mesenteric lymphadenopathy in the absence of pulmonary involvement, diagnosed via biopsy and treated successfully with methotrexate.

## Linked entities

- **Chemicals:** prednisone (PubChem CID 5865), methotrexate (PubChem CID 4112)
- **Diseases:** sarcoidosis (MONDO:0008399)

## Full-text entities

- **Diseases:** GI sarcoidosis (MESH:D012507), systemic disease (MESH:D034721), Abdominal Pain (MESH:D015746), Mesenteric Lymphadenopathy (MESH:D008639), Pulmonary Involvement (MESH:C566343)
- **Chemicals:** prednisone (MESH:D011241), methotrexate (MESH:D008727)

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12253945/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12253945/full.md

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Source: https://tomesphere.com/paper/PMC12253945