# Effect of Fresh Frozen Plasma Infusion on Hospital Length of Stay for Patients With Hereditary Angioedema

## TL;DR

This study finds that fresh frozen plasma infusion may increase hospital stays for hereditary angioedema patients with certain risk factors.

## Contribution

The study identifies FFP infusion as a factor increasing hospital length of stay in patients with specific comorbidities.

## Key findings

- FFP infusion was associated with longer hospital stays in patients with respiratory or cardiovascular conditions.
- Patients with urticaria also experienced increased length of stay following FFP infusion.
- C1-inhibitor therapy is recommended over FFP for personalized treatment.

## Abstract

Background: Patients with hereditary angioedema treated with fresh frozen plasma (FFP) infusion face complications and risk of side effects.

Objective: To study the effect of FFP infusion on hospital length of stay for patients with hereditary angioedema.

Methods: Data from the 2021 Nationwide Inpatient Sample were used to identify hospitalized patients with hereditary angioedema. Patient demographics, comorbidities, and severity measures were analyzed, and a Bayesian additive regression tree model was used to assess factors contributing to length of stay.

Results: FFP infusion was found to be associated with increased length of stay for patients with risk factors such as respiratory, cardiovascular disease, or urticaria.

Conclusions: Caution is recommended when planning to use FFP, to ensure that underlying patient conditions and risk factors are thoroughly understood. The findings emphasize the need for personalized treatment plans based on individual risk factors, with a recommendation for prioritizing C1-inhibitor therapy over FFP.