# Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial

## TL;DR

A 6-month study found that a tocotrienol-enriched drink improved mental well-being, antioxidant defenses, and genomic stability in older adults.

## Contribution

This is the first randomized controlled trial showing tocotrienol's benefits on psychological health and genomic stability in aging populations.

## Key findings

- Tocotrienol supplementation improved psychological quality of life in older adults.
- The supplement enhanced antioxidant markers like TNF-α, T-SOD, and catalase.
- Tocotrienol showed potential to support genomic stability via telomerase activity.

## Abstract

Background: This study investigates the effects of a tocotrienol-enriched drink on oxidative damage and genomic stability in older adults over a 6-month period. Methods: A total of 67 participants (27 males and 40 females, mean age 60.45 ± 5.75 years) were enrolled in this double-blinded, two-arm, parallel randomized controlled trial. Baseline, mid-point, and end-point assessments were conducted to monitor various health parameters. Significant Group × Time interaction effects were observed for several key outcomes. Results: Group A demonstrated significantly better improvements in QOL-Psychological (p = 0.014, Partial Eta Squared = 0.153), suggesting a beneficial impact of tocotrienol supplementation on mental well-being. Additionally, Group A showed more favorable trends in TNF-α (p = 0.04), T-SOD (p = 0.04), catalase (p = 0.02), and telomerase (p = 0.02), suggesting potential antioxidant and genomic stability improvements over time. Conclusions: In a nutshell, tocotrienol supplementation may exert beneficial effects on psychological well-being, oxidative stress modulation, and genomic stability in aging populations.