Insights into the Silver Camphorimine Complexes Interactions with DNA Based on Cyclic Voltammetry and Docking Studies
Joana P. Costa, Gonçalo C. Justino, Fernanda Marques, M. Fernanda N. N. Carvalho
TL;DR
This study uses electrochemical and docking methods to explore how silver camphorimine complexes interact with DNA, helping identify which compounds are most promising for cytotoxic activity.
Contribution
The paper introduces a novel electrochemical approach combined with molecular docking to evaluate DNA interactions of silver camphorimine complexes and their cytotoxic potential.
Findings
All camphorimine silver complexes showed cathodic waves indicating DNA interaction, with shifts in potential when DNA was present.
Molecular docking revealed non-covalent interactions beyond typical DNA binding modes, providing detailed insights into complex-DNA interactions.
The electrochemical shifts correlated with cytotoxic activity, aiding in the prioritization of complexes for further evaluation.
Abstract
Cyclic voltammetry (CV) is an accessible, readily available, non-expensive technique that can be used to search for the interaction of compounds with DNA and detect the strongest DNA-binding from a set of compounds, therefore allowing for the optimization of the number of cytotoxicity assays. Focusing on this electrochemical approach, the study of twenty-seven camphorimine silver complexes of six different families was performed aiming at detecting interactions with calf thymus DNA (CT-DNA). All of the complexes display at least two cathodic waves attributed respectively to the Ag(I)→Ag(0) (higher potential) and ligand based (lower potential) reductions. In the presence of CT-DNA, a negative shift in the potential of the Ag(I)→Ag(0) reduction was observed in all cases. Additional changes in the potential of the waves, attributed to the ligand-based reduction, were also observed. The…
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Taxonomy
TopicsMetal complexes synthesis and properties · DNA and Nucleic Acid Chemistry · Computational Drug Discovery Methods