Synthesis and Transformation of Tricyclic KYNA Derivatives
Julián Robin Sárik, István Szatmári, Bálint Lőrinczi
TL;DR
This paper describes the synthesis of tricyclic KYNA derivatives and their potential as antiviral and anticancer agents.
Contribution
The novel synthesis of tricyclic KYNA derivatives and their reactivity in modified Mannich reactions are presented.
Findings
Tricyclic KYNA derivatives were successfully synthesized and their reactivity studied.
N,N-dimethyl-ethylenediamine analogues were synthesized and tested in modified Mannich reactions.
The compounds show structural similarity to known G-quadruplex binding agents, suggesting potential therapeutic applications.
Abstract
Kynurenic acid (KYNA) derivatives condensed with an aromatic ring (tricyclic KYNA derivatives) have been successfully synthesized, and the reactivity of these analogues has been investigated in the modified Mannich reaction resulting in new Mannich bases. The N,N-dimethyl-ethylenediamine analogues of the tricyclic KYNA derivatives have also been successfully synthesized, and their reactivity in the modified Mannich reaction was investigated. The synthesized ring systems bear resemblance to molecules previously investigated as G-quadruplex binding agents. Based on this similarity, the synthesized tricyclic KYNA derivatives could be investigated as potential antiviral and anticancer molecules.
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Taxonomy
TopicsDNA and Nucleic Acid Chemistry · Synthesis and Biological Evaluation · Chemical Synthesis and Analysis