# Neuroprotective Effects and Mechanisms of Alpiniae oxyphyllae Fructus, a Medicinal and Edible Homologous Herb: Research Advances

## TL;DR

This review summarizes how Alpiniae oxyphyllae Fructus protects the brain and its potential for treating neurological diseases.

## Contribution

The paper provides a systematic review of recent advancements in understanding the neuroprotective mechanisms and clinical applications of AOF.

## Key findings

- AOF inhibits neuronal apoptosis and reduces oxidative stress.
- It alleviates neuroinflammation and regulates nerve cell balance.
- Recent studies show significant clinical progress in using AOF for neurological disorders.

## Abstract

Neurological diseases, which include various neurodegenerative disorders, not only impair patients’ physical health but also impact their psychological and social functions. It is particularly urgent to seek effective prevention and treatment strategies for neurological diseases. Alpiniae oxyphyllae Fructus (AOF), a traditional Chinese medicinal herb, has been widely used in treating urinary, digestive, and neurological disorders. Contemporary medical research has demonstrated that AOF exerts neuroprotective effects through multiple mechanisms, including by inhibiting neuronal apoptosis, alleviating neuroinflammation, reducing oxidative stress, and regulating nerve cell dynamic balance. In recent years, substantial advancements have been achieved in investigations concerning the neuroprotective effects and underlying mechanisms of AOF, alongside significant breakthroughs in its clinical applications. This review systematically summarizes the neuroprotective effects of AOF and delineates its clinical applications, thereby offering valuable reference and guidance for the prevention and treatment of neurological diseases using AOF.