# Association of Tissue Expression of LAG-3 and TIM-3 with Clinical Features in Ovarian Cancer

## TL;DR

This study explores the link between LAG-3 and TIM-3 protein expression in ovarian cancer tissue and clinical features like BMI and age.

## Contribution

The study identifies potential associations between LAG-3 and TIM-3 expression and clinical features in ovarian cancer subtypes.

## Key findings

- LAG-3 expression is associated with BMI in non-HGSOC ovarian cancer patients.
- TIM-3 expression is linked to age in all ovarian cancer patients.
- LAG-3 and TIM-3 expression levels are correlated across all studied groups.

## Abstract

One of the most prevalent types of cancer among women is ovarian cancer. The search for ovarian cancer markers is constantly ongoing. Evaluation of LAG-3 and TIM-3 protein expression in ovarian cancer tissue and its role in distinguishing the clinical signs stated were the objectives of this study. Methods: A total of 58 ovarian cancer patients were recruited for this study. The cohort was split into two groups: one for high-grade serous ovarian cancer (HGSOC) and another for ovarian cancer that was not HGSOC (non-HGSOC). LAG-3 and TIM-3 protein expression in ovarian cancer tissue samples was evaluated by immunohistochemistry. StatView 5.0 software (Carry, NC, USA) was used for all statistical analyses. Both LAG-3 and TIM-3 proteins mostly showed positive, moderately positive, or strongly positive expression. This study shows that LAG-3 could be a marker associated with BMI in the non-HGSOC group. TIM-3 may be a marker associated with age in a group of all ovarian cancers. LAG-3 expression is associated with TIM-3 expression in the total cohort and the HGSOC and non-HGSOC groups.