# Exosomes Derived from Induced and Wharton’s Jelly-Derived Mesenchymal Stem Cells Promote Senescence-like Features and Migration in Cancer Cells

## TL;DR

Exosomes from different types of stem cells affect cancer cells differently, with some promoting aging-like states and others encouraging cell movement.

## Contribution

The study reveals distinct effects of exosomes from iMSCs and WJMSCs on cancer cell behavior, emphasizing the importance of source selection.

## Key findings

- Exosomes from both iMSCs and WJMSCs reduced MCF7 proliferation and induced a senescence-like state.
- WJMSC-derived exosomes promoted migration in MCF7 and A549 cells, unlike iMSC-derived exosomes.
- WJMSC exosomes had a stronger impact on cancer cell proliferation and migration compared to iMSC exosomes.

## Abstract

Mesenchymal stem cell-derived exosomes (MSC-Exos) play a key role in tissue repair, immune regulation, and cancer biology. Due to limitations in MSC expansion and source variability, interest has shifted to induced pluripotent stem cell-derived MSCs (iMSCs) as a promising alternative. This study compares effects of exosomes derived from iMSCs (iMSC-Exos) and Wharton’s jelly MSCs (WJMSC-Exos) on MCF7 and A549 cancer cells. Both types of exosomes reduced MCF7 proliferation and induced a senescence-like state, rather than apoptosis, although the antiproliferative effect was transient in A549 cells. Notably, WJMSC-Exos promoted migration in both MCF7 and A549, whereas iMSC-Exos did not exhibit this effect. Overall, WJMSC-Exos had a more robust impact on cancer cell proliferation and migration. These findings highlight the diverse effects of exosomes on cancer and the development of a senescence-like state as an important response to Exos exposure. Moreover, these findings invite for more careful evaluation of the therapeutic role of iMSC-derived Exos.