# From Nuclear Receptor Regulation to Spleen Activating and Accumulation Resolving Therapy: A Review of Traditional Chinese Medicine Against Diabetes and Inflammation

## TL;DR

This review explores how nuclear receptors in the liver regulate metabolism and inflammation in diabetes and how traditional Chinese medicine may help.

## Contribution

Highlights new insights into hepatic nuclear receptor signaling and TCM's role in diabetes therapy.

## Key findings

- Nuclear receptors regulate metabolism and inflammation in diabetic patients.
- Hepatic nuclear receptor signaling is key to inter-organ communication in diabetes.
- Traditional Chinese medicine shows promise in targeting nuclear receptors for diabetes treatment.

## Abstract

Nuclear receptors are proteins located in the nucleus that are involved in gene transcription and play an important role in regulating metabolism and inflammation. Systemic metabolic abnormalities and chronic inflammation in diabetic patients are associated with gene expression and activity of bile acid metabolism, lipid and carbohydrate metabolism, energy expenditure, and inflammation regulated by nuclear receptors. As a major metabolic organ, the nuclear receptor regulation signal of the liver is the key to regulating the dialog between the liver and other organs. In this review, we discuss the newly discovered role of hepatic nuclear receptor signaling in diabetes metabolism and inflammation and focus on recent advances in drug research targeting nuclear receptors in diabetes, including the use of traditional Chinese medicine.