# Hypernatremia, Hyperlipemia and Hemorrhagic Enteritis in a Hypodipsic Dog with Corpus Callosum Dysplasia

## TL;DR

A young dog with brain development issues experienced severe dehydration and high fat levels, leading to intestinal bleeding and liver problems.

## Contribution

This paper reports a rare case linking hypodipsia, corpus callosum dysplasia, and complications like hypernatremia and hemorrhagic enteritis in a dog.

## Key findings

- Hypernatremia and hyperlipemia were consistently associated in a hypodipsic dog with corpus callosum dysplasia.
- Restoring water intake corrected hypernatremia and resolved hyperlipemia.
- Hemorrhagic enteritis was suspected to result from chronic hypernatremia and hyperlipidemia.

## Abstract

We report a rare case of hypodipsia in a 7-month-old female Labrador Retriever with congenital corpus callosum dysplasia, presented for hemorrhagic enteritis. The hypodipsia-induced hypernatremic crisis was consistently associated with severe hyperlipemia, which resolved upon adequate water intake and sodium correction.

This case describes a rare presentation of hypodipsia in a 7-month-old female Labrador Retriever, attributed to congenital corpus callosum dysplasia and holoprosencephaly. Chronic hypernatremia in the patient was consistently associated with severe hyperlipemia, which was further complicated by hemorrhagic enteritis and sepsis-associated liver dysfunction. Persistent hyperlipemia was observed during the hypernatremic crisis but resolved following the restoration of adequate water intake and the subsequent correction of hypernatremia. The association between hyperlipemia and hypernatremia is unusual, with only a limited number of cases reported in pediatric patients and a single canine case involving encephalic lymphosarcoma. The hemorrhagic enteritis observed in this patient was suspected to be a complication of the chronic hypernatremic and hyperlipidemic state. This report explores the relevant literature and proposes potential pathophysiological mechanisms underlying the interplay between these clinical findings and altered thirst regulation caused by corpus callosum dysplasia.